Two sample MR report
HLA-DQA2_Monocyte (Mono) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 114 | -0.0681255 | 0.0321906 | 0.0365328 |
| Weighted median | 114 | -0.0008992 | 0.0047253 | 0.8490798 |
| Inverse variance weighted | 114 | 0.0363423 | 0.0071505 | 0.0000004 |
| Simple mode | 114 | 0.1047768 | 0.0047805 | 0.0000000 |
| Weighted mode | 114 | -0.0149113 | 0.0038722 | 0.0001956 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2396.726 | 112 | 0 |
| Inverse variance weighted | 2632.800 | 113 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1245314 | 0.0374934 | 0.0012098 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0042768 | 2.4e-05 | TRUE | 0 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
